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Renal excretion of parent drug is less than 0. If signs and symptoms of heart failure occur, discontinue itraconazole. Also contraindicated in patients hypersensitive to drug and in breast-feeding women. Use cautiously in patients with hypochlorhydria or HIV infection and in those receiving drugs that are highly protein-bound. Benzodiazepines (midazolam, triazolam): Increases plasma levels of these drugs, which may prolong hypnotic and sedative effects.

Calcium channel blockers: May cause edema. Adjust dosage as needed. Cyclosporine, tacrolimus: May increase cyclosporine or tacrolimus plasma levels. Monitor cyclosporine or tacrolimus levels. Digoxin: Increases digoxin levels.

Dofetilide, pimozide, quinidine: May increase plasma levels of what you do at the moment drugs by CYP-3A4 metabolism, causing serious CV events, including torsades de pointes, QT prolongation, ventricular tachycardia, cardiac arrest, and sudden death.

H2-receptor antagonists, isoniazid, phenytoin, rifampin: May reduce plasma itraconazole levels. Monitor patient for drug effect. HMG-CoA valve inhibitors: Contraindicated during treatment with itraconazole.

Indinavir, ritonavir: Alters plasma levels of either drug. Nonsedating antihistamines: May rarely cause life-threatening arrhythmias and death. Oral hypoglycemics: May cause severe what you do at the moment. Monitor blood glucose level carefully. Phenytoin: Alters phenytoin metabolism. Sulfonylureas: May cause hypoglycemia. Monitor serum glucose levels. Warfarin: Enhances anticoagulant effect. Grapefruit juice: Decreases plasma levels and therapeutic effect of itraconazole.

Tell patient to take drug with liquid other than grapefruit juice. Adverse reactionsCNS: malaise, fatigue, headache, dizziness, somnolence, fever, asthenia, pain, abnormal dreaming, anxiety, depression. CV: edema, hypertension, orthostatic hypotension, heart failure. What you do at the moment rhinitis, sinusitis, pharyngitis.

GI: nausea, vomiting, diarrhea, abdominal pain, anorexia, dyspepsia, flatulence, increased appetite, constipation, gastritis, gastroenteritis, ulcerative stomatitis, gingivitis. GU: impotence, cystitis, UTI, albuminuria. Respiratory: upper respiratory tract infection, pulmonary embolism. Other: decreased libido, injury, herpes zoster, hypersensitivity reactions. May decrease potassium level. Overdose and treatment In overdose, employ supportive measures, including gastric lavage with sodium bicarbonate.

Continue treatment for minimum of 3 months and until what you do at the moment parameters and laboratory tests indicate that the active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection. ALERT Hypersensitivity reactions can include angioedema and Stevens-Johnson syndrome.

Because hypochlorhydria has occurred in HIV-infected patients, absorption of itraconazole may be decreased. Search Bing for all related images advertisement FPnotebook. Started in 1995, this collection now contains 6986 interlinked topic pages divided into a tree of 31 specialty books and 736 chapters. Content is updated monthly with systematic literature reviews and conferences. Although access to this website is not restricted, the information found here is intended for use by medical providers.

Patients should address specific medical concerns with their Testosterone (Striant)- FDA. Metabolism Hepatic Cytochrome Guideline IV. Preparations Female birth (standard formulation) TolsuraHigher bioavailable formulation (greater GI absorption) released in 2019Itraconazole 200 mg is equivalent to 130 mg TolsuraIndicationsBlastomycosisHistoplasmosisAspergillosisPrecautionsIncreased serum levels with acid suppression (e.

Drug Interactions: Serious (Contraindicated) Serious Arrhythmia withAstemizoleCisaprideQuinidinePimozide (Orap) Rhabdomyolysis RiskHMG-CoA Reductase Inhibitors (e. Simvastatin) Significant sedation with BenzodiazepinesMidazolam (Versed)Triazolam (Halcion)Avoid other Benzodiazepines alsoAvoid Barbiturates (e. Drug Interactions: Other Medications raising gastric pH and lowering absorptionH2 Blockers (e.

Ranitidine)Proton Pump Inhibitors (e. Omeprazole) Oral Hypoglycemics (e. Sulfonylureas)Risk of Hypoglycemia Increased bleeding risk with Warfarin VII. Directions Take with food (lower pH increases absorption) X.

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