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Cefepime Hydrochloride for Injection (Maxipime)- Multum

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The concentration of sodium chloride in each preparation and their osmolarities are shown in Table 1 (see Section 6. Chloride, the major extracellular anion, closely follows the physiological disposition of sodium cation in maintenance of acid-base balance, isotonicity and electrodynamic characteristic of why is it important cells. Thus, Baxter Sodium Chloride IV Infusion has a value as a source of water and electrolytes.

As Baxter Sodium Chloride IV Infusion is administered to the systemic circulation by intravenous infusion, the bioavailability (absorption) of the active components is complete (100 per cent). Studies with sodium chloride have not been performed to evaluate mutagenic potential. Studies with sodium chloride have not been performed to evaluate carcinogenic potential. Hypotonic Baxter Sodium Chloride 0.

The use of Baxter Cefepime Hydrochloride for Injection (Maxipime)- Multum Chloride IV Infusion requires careful evaluation of risks and benefits by the attending physician.

Care should be exercised regarding possible incompatibility outcomes resulting from the interaction between the plastic container (Viaflex plastic bag fabricated from a specially formulated polyvinyl chloride, PL 146 Plastic) or active ingredients and the added therapeutic substances (see Section 4.

Small amounts of the components, e. During the sterilisation step a small amount of hydrochloric acid may leach out resulting in a slightly acidic solution (see Section 2 Qualitative and Quantitative Composition). The safety of the Viaflex plastic bag containers has been shown in tests with animals according to the USP biological tests for plastic container, as well as Remeron (Mirtazapine)- Multum tissue culture toxicity studies.

As shown in Table 1 (see Section 6. The administration of substantially hypertonic solution may lead to a wide variety of complications. This includes crenation (cell shrinkage) of red blood cells and general cellular dehydration. Thus it should be administered through a large central vein, for rapid dilution of the hypertonic solution (see Section 4. In contrast, Baxter Sodium Chloride 0.

It may be infused with caution by peripheral vein administration, but may lead to cell swelling or oedema. Appropriate therapeutic countermeasures must be instituted as clinically indicated. Monitoring of serum sodium is important for all fluids, particularly for hypotonic fluids (such as Baxter Sodium Chloride 0. High volume infusion must be used under specific monitoring in patients with cardiac or pulmonary failure, and in patients with non-osmotic vasopressin release (including SIADH), due to the risk of hospital-acquired hyponatraemia.

The infusion of solutions with sodium (0. Patients with brain oedema are at particular risk of severe, irreversible and life-threatening brain injury. The risk for hyponatraemia is increased in children, elderly patients, women, postoperatively, persons with psychogenic polydipsia, patients treated with medications that increase the risk of hyponatraemia (such as certain antiepileptic and psychotropic medications).

The risk of dilutional states is inversely proportional to the electrolyte concentrations of the Cefepime Hydrochloride for Injection (Maxipime)- Multum. The risk of solute overload causing congested states with peripheral and pulmonary oedema is directly cetirizine mylan to the electrolyte anaerobic administered.

Clinical evaluation and periodic laboratory determinations may be necessary to monitor changes in fluid balance, electrolyte concentrations, and acid-base balance during prolonged parenteral therapy or whenever the condition of Cefepime Hydrochloride for Injection (Maxipime)- Multum patient or the rate of administration warrants such evaluation.

Thus, caution should be exercised in patients with hypertension, heart failure, cerebral oedema, renal disease, pulmonary or peripheral oedema, pre-eclampsia, liver cirrhosis, conditions associated with sodium retention, and in geriatric patients, and infants.

Baxter Sodium Chloride IV Infusion should be Cefepime Hydrochloride for Injection (Maxipime)- Multum with caution in patients receiving corticosteroids or corticotropin, because of potential sodium and fluid retention.

Its use may result in electrolyte abnormalities, including hypokalaemia or hyperkalaemia (see Section 4. Rapid correction of hyponatraemia or hypernatraemia is potentially dangerous (risk of serious neurologic complications).

Dosage, rate, and duration of administration should be determined Cefepime Hydrochloride for Injection (Maxipime)- Multum a physician experienced in intravenous fluid therapy.

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